Dmel microbiome is dominated by Acetic acid bacteria (AABs), mainly genus Acetobacter (Alphaproteobacteria), Lactic acid bacteria (LABs), mainly the genus Lactobacillus (Firmicutes) (20). And also a strong representation of other taxa, including Gammaproteobacteria (e.g., Stenotrophomonas spp.) and lactobacilli (e.g., Enterococcus spp.) (22, 23). Acetobacter fabarum, Acetobacter pomorum, Acetobacter tropicalis, Lactobacillus brevis, and Lactobacillus plantarum.