Chromatin bridges

Healthy cell division:

  • Metaphase: Chromosomes line up at the cell’s center.

  • Anaphase: Chromosomes separate cleanly toward opposite poles.

  • Telophase: Two nuclei form with fully separated DNA.

  • Result: two daughter cells with the correct DNA, stable genome.

Unhealthy division with chromatin bridges:

  • Metaphase: Chromosomes may be tangled or improperly aligned.

  • Anaphase: Some chromosomes fail to separate, and their DNA gets stretched between the two poles.

  • Telophase: Thread-like DNA bridges remain between nuclei.

  • Result: DNA may break or mis-segregate, producing cells with abnormal DNA and genomic instability.

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